Self-assessed health (SAH) is a widely used tool to estimate population health. However, the debate continues as to what exactly this ubiquitous measure of social science research means for policy conclusions. This study is aimed at understanding the tenability of the construct of SAH by simultaneously modelling SAH and clinical morbidity. Using data from 17 waves (2001–2017) of the Russian Longitudinal Monitoring Survey, which captures repeated response for SAH and frequently updates information on clinical morbidity, we operationalise a recursive semi-ordered probit model. Our approach allows for the estimation of the distributional effect of clinical morbidity on perceived health. This study establishes the superiority of inferences from the recursive model. We illustrated the model use for examining the endogeneity problem of perceived health for SAH, contributing to population health research and public policy development, in particular, towards the organisation of health systems. Full article

Ionospheric clutter is one of the main problems for high-frequency surface wave radars (HFSWRs), as it severely interferes with sea surface state monitoring and target detection. Although a number of methods exist for ionospheric clutter suppression, most are suitable for radars with a large-sized array and are inefficient for small-aperture radars. In this study, we added an auxiliary crossed-loop antenna to the original compact radar antenna, and used an adaptive filter to suppress the ionospheric clutter. The experimental results of the HFSWRs data indicated that the suppression factor of the ionospheric clutter was up to 20 dB. Therefore, the Bragg peaks that were originally submerged by the ionospheric clutters could be recovered, and the gaps in the current maps can, to a large extent, be filled. For an oceanographic radar, the purpose of suppressing ionospheric clutter is to extract an accurate current speed; the radial current fields that were generated by our method showed an acceptable agreement with those generated by GlobCurrent data. This result supports the notion that the ionospheric suppression technique does not compromise the estimation of radial currents. The proposed method is particularly efficient for a compact HFSWRs, and can also be easily used in other types of antennas. Full article

The behavioural integrity of leaders is not only an individual trait that can earn them respect in their personal capacity, but it also may positively affect their followers and ultimately improve the organization’s effectiveness in a variety of ways. The relationship between behavioural integrity and employees using their voice has been studied by researchers through multiple aspects. This study brings a new perspective in this discussion by investigating the effect of leaders’ behavioural integrity on employees’ voice both directly and through the mediating roles of psychological safety and trust in the leader. The cross-sectional data of 384 employees collected from the banking sector in Pakistan is used to shed light on this new perspective in the relationship between the behavioural integrity of a leader and employees’ comportment in using their voice. The results of the empirical analyses support the direct effect of the behavioural integrity of leaders on employees’ voice. A significant mediating role of psychological safety and trust is also supported in the empirical analyses. The findings of the study bear important implications for leaders and business managers working in companies by providing insight on the importance of behavioural integrity of leaders in encouraging employees to have a voice in organizations. Full article

The Charge-Displacement (CD) analysis has proven to be a powerful tool for a quantitative characterization of the electron-density flow occurring upon chemical bonding along a suitably chosen interaction axis. In several classes of interesting intermolecular interactions, however, an interaction axis cannot be straightforwardly defined, and the CD analysis loses consistency and usefulness. In this article, we propose a general, flexible reformulation of the CD analysis capable of providing a quantitative view of the charge displacement along custom curvilinear paths. The new scheme naturally reduces to ordinary CD analysis if the path is chosen to be a straight line. An implementation based on a discrete sampling of the electron densities and a Voronoi space partitioning is described and shown in action on two test cases of a metal-carbonyl and a pyridine-ammonia complex. Full article

Based on the Tao and Kong (TK) model and the fractal model of the soil–water characteristic curve, a simplified model of the relationship between the saturated permeability coefficient and the air-entry value is established in this study: k_s = k₀ψ_a⁻². It is shown that the saturated permeability coefficient of soil is determined by its maximum pore size. In order to facilitate the mutual prediction of saturation permeability coefficient and air-entry value, based on the data of five types of soil in the UNSODA database, the comprehensive proportionality constant k₀ of the five types of soil were obtained: sand k₀ = 0.03051; clay k₀ = 0.001878; loam k₀ = 0.001426; sandy loam k₀ = 0.009301; and silty clay loam k₀ = 0.0007055. Based on the obtained comprehensive proportionality constant k₀ and the relationship model between saturated permeability coefficient and air intake value, the air-entry value of five kinds of soils in the existing literature and the SoilVision database were calculated. Comparing the calculated air-entry value with the measured one, the results showed that the model simplifies the traditional air-entry value prediction method to some extent and can effectively predict the air-entry value of different types of soil. On the whole, the model better predicts the air-entry value for sandy, clay, and silty clay loam than loam and sandy loam. Full article

This paper reviews current research on the microbial life that surrounds vertebrate embryos. Several clades are believed to develop inside sterile—or near-sterile—embryonic microhabitats, while others thrive within a veritable zoo of microbial life. The occurrence of embryo-associated microbes in some groups, but not others, is an under-appreciated transition (possibly transitions) in vertebrate evolution. A lack of comparable studies makes it currently impossible to correlate embryo-associated microbiomes with other aspects of vertebrate evolution. However, there are embryonic features that should instruct a more targeted survey. This paper concludes with a hypothesis for the role of multiciliated surface cells in amphibian and some fish embryos, which may contribute to managing embryo-associated microbial consortia. These cells are known to exist in some species that harbor in ovo microbes or have relatively porous egg capsules, although most have not been assayed for embryo-associated microbiota. Whether the currents generated within these extraembryonic microhabitats contribute to culturing consistent microbial communities remains to be seen. Full article

In previous work, it was shown that if certain series based on sums over primes of non-principal Dirichlet characters have a conjectured random walk behavior, then the Euler product formula for its L-function is valid to the right of the critical line $\Re \left(s\right)>\frac{1}{2}$, and the Riemann hypothesis for this class of L-functions follows. Building on this work, here we propose how to extend this line of reasoning to the Riemann zeta function and other principal Dirichlet L-functions. We apply these results to the study of the argument of the zeta function. In another application, we define and study a one-point correlation function of the Riemann zeros, which leads to the construction of a probabilistic model for them. Based on these results we describe a new algorithm for computing very high Riemann zeros, and we calculate the googol-th zero, namely ${10}^{100}$-th zero to over 100 digits, far beyond what is currently known. Of course, use is made of the symmetry of the zeta function about the critical line. Full article

Cancer cells exhibit an increased glycolysis rate for ATP generation (the Warburg effect) to sustain an increased proliferation rate. In tumor cells, the oxidation of pyruvate in the Krebs cycle is substituted by lactate production, catalyzed by LDH. In this study, we use ethoxyquin (EQ) as a novel inhibitor to target LDH in murine Ehrlich ascites carcinoma (EAC) and as a combination therapy to improve the therapeutic efficacy of the conventional chemotherapy drug, cisplatin (CIS). We investigated the anti-tumor effect of EQ on EAC-bearing mice and checked whether EQ can sustain the anti-tumor potential of CIS and whether it influences LDH activity. Treatment with EQ had evident anti-tumor effects on EAC as revealed by the remarkable decrease in the expression of the anti-apoptotic gene Bcl-2 and by a significant increase in the expression of apoptotic genes (BAX and caspase-3). EQ also caused a significant decrease in the autophagic activity of EAC cells, as shown by a reduction in the fluorescence intensity of the autophagosome marker. Additionally, EQ restored the altered hematological and biochemical parameters and improved the disrupted hepatic tissues of EAC-bearing mice. Co-administration of EQ and CIS showed the highest anti-tumor effect against EAC. Collectively, our findings propose EQ as a novel inhibitor of LDH in cancer cells and as a combinatory drug to increase the efficacy of cisplatin. Further studies are required to validate this therapeutic strategy in different cancer models and preclinical trials. Full article

Transfer RNA^[Ser]Sec carries multiple post-transcriptional modifications. The A37G mutation in tRNA^[Ser]Sec abrogates isopentenylation of base 37 and has a profound effect on selenoprotein expression in mice. Patients with a homozygous pathogenic p.R323Q variant in tRNA-isopentenyl-transferase (TRIT1) show a severe neurological disorder, and hence we wondered whether selenoprotein expression was impaired. Patient fibroblasts with the homozygous p.R323Q variant did not show a general decrease in selenoprotein expression. However, recombinant human TRIT1^R323Q had significantly diminished activities towards several tRNA substrates in vitro. We thus engineered mice conditionally deficient in Trit1 in hepatocytes and neurons. Mass-spectrometry revealed that hypermodification of U₃₄ to mcm⁵Um occurs independently of isopentenylation of A₃₇ in tRNA^[Ser]Sec. Western blotting and ⁷⁵Se metabolic labeling showed only moderate effects on selenoprotein levels and ⁷⁵Se incorporation. A detailed analysis of Trit1-deficient liver using ribosomal profiling demonstrated that UGA/Sec re-coding was moderately affected in Selenop, Txnrd1, and Sephs2, but not in Gpx1. 2′O-methylation of U₃₄ in tRNA^[Ser]Sec depends on FTSJ1, but does not affect UGA/Sec re-coding in selenoprotein translation. Taken together, our results show that a lack of isopentenylation of tRNA^[Ser]Sec affects UGA/Sec read-through but differs from a A37G mutation. Full article

The regulation of oxygen and blood supply during isometric muscle actions is still unclear. Recently, two behavioral types of oxygen saturation (SvO₂) and relative hemoglobin amount (rHb) in venous microvessels were described during a fatiguing holding isometric muscle action (HIMA) (type I: nearly parallel behavior of SvO₂ and rHb; type II: partly inverse behavior). The study aimed to ascertain an explanation of these two regulative behaviors. Twelve subjects performed one fatiguing HIMA trial with each arm by weight holding at 60% of the maximal voluntary isometric contraction (MVIC) in a 90° elbow flexion. Six subjects additionally executed one fatiguing PIMA trial by pulling on an immovable resistance with 60% of the MVIC with each side and same position. Both regulative types mentioned were found during HIMA (I: n = 7, II: n = 17) and PIMA (I: n = 3, II: n = 9). During the fatiguing measurements, rHb decreased initially and started to increase in type II at an average SvO₂-level of 58.75 ± 2.14%. In type I, SvO₂ never reached that specific value during loading. This might indicate the existence of a threshold around 59% which seems to trigger the increase in rHb and could explain the two behavioral types. An approach is discussed to meet the apparent incompatibility of an increased capillary blood filling (rHb) despite high intramuscular pressures which were found by other research groups during isometric muscle actions. Full article

Rapid urbanization has produced serious heat effects worldwide. However, the literature lacks a detailed study on heat effects based on the directions and types of urban expansion. In this work, a typical city with an extremely hot summer climate, Hangzhou, was selected as a case study to determine the relationships between the urban heat-effect dynamics and spatiotemporal patterns of impervious surface expansion. Based on long-term Landsat imagery, this study characterized the spatiotemporal patterns of urban expansion and normalized surface temperatures in Hangzhou City from 2000 to 2020 using object-based backdating classification and a generalized single-channel algorithm with the help of a land-use transfer matrix, expansion index, and spatial centroids. Relevant policies, industries, and traffic networks were discussed to help explain urban expansion and thermal environment changes. The results demonstrated that in 2020, the area of impervious surfaces covered 1139.29 km². The majority of the gains were in farmland, water, and forests, and the annual growth rate was 32.12 km²/year beginning in 2000. During the expansion of impervious surfaces, the city warmed at a slower rate, and more thermal contributions came from sub-urban areas. The southeast-oriented expansion of impervious surfaces was the key reason for the spatiotemporal dynamics of the urban heat effects. The dominant urban edge expansion intensified the local heat effects. This research provides a Landsat-based methodology for better understanding the heat effects of urban expansion. Full article

This paper uses computational fluid dynamics (CFD) to simulate flow field distribution inside an electrochemical descaling reactor in three dimensions. First, the reactor flow field was obtained by steady-state simulation, and the grid independence was verified. Then, the steady state of the flow field was judged to ensure the accuracy of the simulation results. Transient simulations were performed on the basis of steady-state simulations, and residence time distribution (RTD) curves were obtained by a pulse-tracing method. The effects of plate height and plate spacing on reactor hydraulic characteristics (flow state and backmixing) were investigated using RTD curves, and the results showed that increasing the plate height and decreasing the plate spacing could make the flow more similar to the plug flow and reduce the degree of backmixing in the reactor. The flow field details provided by CFD were used to analyze the reactor flow field and were further verified to obtain the distribution patterns of dead and short circuit zones. Meanwhile, information regarding pressure drops was extracted for different working conditions (490, 560, and 630 mm for pole plate height and 172.6, 129.45, and 103.56 mm for pole plate spacing), and the results showed that increasing the pole plate height and decreasing the pole plate spacing led to an increased drop in pressure. In this case, a larger pressure drop means higher energy consumption. However, increasing the pole plate height had a smaller effect on energy consumption than decreasing the pole plate spacing. Full article

Compliant mechanisms’ design aims to create a larger workspace and simple structural shapes because these mechanical systems usually have small dimensions, reduced friction, and less bending. From that request, we designed optimal bridge-type compliant mechanism flexure hinges with a high magnification ratio, low stress by using a flexure joint, and especially no friction and no bending. This joint was designed with optimal dimensions for the studied mechanism by using the method of grey relational analysis (GRA), which is based on the Taguchi method (TM), and finite element analysis (FEA). Grey relational grade (GRG) has been estimated by an artificial neural network (ANN). The optimal values were in good agreement with the predicted value of the Taguchi method and regression analysis. The finite element analysis, signal-to-noise analysis, surface plot, and analysis of variance demonstrated that the design dimensions significantly affected the equivalent stress and displacement. The optimal values of displacement were also verified by the experiment. The outcomes were in good agreement with a deviation lower than 6%. Specifically, the displacement amplification ratio was obtained as 65.36 times compared with initial design. Full article

There has been considerable interest in inorganic scintillators based on lutetium due to their favorable physical properties. Despite their advantages, lutetium-based scintillators could face issues because of the natural occurring radioisotope of ¹⁷⁶Lu that is contained in natural lutetium. In order to mitigate its potential shortcomings, previous works have studied to understand the energy spectrum of the intrinsic radiation of ¹⁷⁶Lu (IRL). However, few studies have focused on the various principal types of photon interactions with matter; in other words, only the full-energy peak according to the photoelectric effect or internal conversion have been considered for understanding the energy spectrum of IRL. Thus, the approach we have used in this study considers other principal types of photon interactions by convoluting each energy spectrum with combinations for generating the spectrum of the intrinsic radiation of ¹⁷⁶Lu. From the results, we confirm that the method provides good agreement with the experiment. A significant contribution of this study is the provision of a new approach to process energy spectra induced by mutually independent radiation interactions as a single spectrum. Full article

Organisations use non-standard employment as a means of flexibility and reduction of fixed costs. An increasingly growing group of employees are self-employed, have work contracts such as part-time and temporary contracts or are employed by a temporary agency, a development catalysed by the COVID pandemic. Whereas there is some evidence that temporary work might affect health via job insecurity (JI )there are hardly any studies focussing on the effects and mechanisms of temporary agency work (TAW). This study sheds light on TAW’s potential health impact and the role of JI in this respect using a mediation analysis. Based on the BIBB/BAuA-Employment Survey 2018 (N = 20.021, representative of the German working population), we analysed the direct effect of TAW on cognitive and psychosomatic aspects of well-being. In particular, we considered JI as mediator for this association. In line with the potentially detrimental effects of temporary employment on well-being, we found that TAW was related to unfavourable outcomes in terms of job satisfaction, general health status and musculoskeletal complaints. JI partially mediated all three underlying associations. Organisations need to be flexible and adaptable. However, by using temporary agency employment as a means to achieve this flexibility, managers and leaders should be aware that it is related to unfavourable well-being and hence hidden costs. In using this type of employment, both the temporary work agency and the user company should consider these health risks by providing health care, options for increasing the temporary agency workers (TA), workers employability, and equal treatment between permanent and TA workers at the actual workplace. Full article

This study aimed to evaluate the ability of the response surface methodology (RSM) approach to predict the tractive performance of an agricultural tractor during semi-deep tillage operations. The studied parameters of tractor performance, including slippage (S), drawbar power (DP) and traction efficiency (TE), were affected by two different types of tillage tool (paraplow and subsoiler), three different levels of operating depth (30, 40 and 50 cm), and four different levels of forward speed (1.8, 2.3, 2.9 and 3.5 km h⁻¹). Tractors drove a vertical load at two levels (225 kg and no weight) in four replications, forming a total of 192 datapoints. Field test results showed that all variables except vertical load, and different combinations of this and other variables, were effective for the S, DP and TE. Increments in speed and depth resulted in an increase and decrease in S and TE, respectively. Additionally, the RSM approach displayed changes in slippage, drawbar power and traction efficiency, resulting from alterations in tine type, depth, speed and vertical load at 3D views, with high accuracy due to the graph’s surfaces, with many small pixels. The RSM model predicted the slippage as 6.75%, drawbar power as 2.23 kW and traction efficiency as 82.91% at the optimal state for the paraplow tine, with an operating depth of 30 cm, forward speed of 2.07 km h⁻¹ and a vertical load of 0.01 kg. Full article

Carbon catabolite repression (CCR) is critical for the preferential utilization of glucose derived from environmental carbon sources and regulated by carbon catabolite repressor A (Cre1/CreA) in filamentous fungi. However, a role of Cre1-mediated CCR in insect-pathogenic fungal utilization of host nutrients during normal cuticle infection (NCI) and hemocoel colonization remains explored insufficiently. Here, we report an indispensability of Cre1 for Beauveria bassiana’s utilization of nutrients in insect integument and hemocoel. Deletion of cre1 resulted in severe defects in radial growth on various media, hypersensitivity to oxidative stress, abolished pathogenicity via NCI or intrahemocoel injection (cuticle-bypassing infection) but no change in conidial hydrophobicity and adherence to insect cuticle. Markedly reduced biomass accumulation in the Δcre1 cultures was directly causative of severe defect in aerial conidiation and reduced secretion of various cuticle-degrading enzymes. The majority (1117) of 1881 dysregulated genes identified from the Δcre1 versus wild-type cultures were significantly downregulated, leading to substantial repression of many enriched function terms and pathways, particularly those involved in carbon and nitrogen metabolisms, cuticle degradation, antioxidant response, cellular transport and homeostasis, and direct/indirect gene mediation. These findings offer a novel insight into profound effect of Cre1 on the insect-pathogenic lifestyle of B. bassiana. Full article

Protected areas play an important role in the conservation and protection of biodiversity of particular territories, especially of ecosystems that provide resources for living organisms, including human beings. Different studies highlight the importance of biodiversity and its associated benefits in terms of ecosystem services of protected areas. The economic assessment of ecosystem services and biodiversity becomes a viable solution to help the policy maker to make decisions on the environmental preservation of these areas according to the Agenda 2030 for Sustainable Development. Nonetheless, very few studies provide an economic evaluation of the benefits of protected areas. To advance the current debate on the economic evaluation of the benefits provided by protected areas, the present paper purposes an integrated approach. It presents an overview of main ecosystem services’ mapping techniques currently available to researchers and policy makers and offers a systematic review carried out for the period 2015–2020 at an international level. The main findings are particularly attractive for the Gargano National Park (GNP) in the south of Italy, which is recognised as being a biodiversity hot spot at global level. The current study provides useful guidance for the assessment of trade-offs, the support to policy makers, and the provision of efficient allocation of public resources for protected areas. Full article

The cooling effect of turbine vane is of great importance for ensuring thermal protection and economic operation of gas turbines. This study aims to reveal the influence mechanism and performance of impingement cooling and heat transfer within a turbine guide vane cavity. Then, a turbine guide vane cavity with a complex pin fins structure is numerically investigated at a multi-hole impingement by comparison with experiment verification. The results show that the larger the Reynolds number is, the larger the average Nusselt number is on the upper and lower surfaces of the cavity. The average Nusselt number increased on the upper and lower surfaces as the impingement hole diameter increased. Comparing 1 impingement hole with 16 ones, the average Nusselt number of the lower surface of the latter is 553.9% larger than that of the former. Furthermore, the average Nusselt number of the lower surface for pin fin height of 3 mm is only improved by 11.2% for pin fin height of 24 mm. The heat transfer effect near the impingement holes is better than that far away from the impingement holes. In particular, it is recommended to have 14 impingement holes with a hole diameter of 7.2 mm, as well as circular pin fins with a height of 3 mm and spacing of 25.8 mm. In addition, the entropy generation distribution in impingement cooling is analyzed. This study can provide a reference to enhance the turbine vane cooling performance by optimization design. Full article

This study evaluates the accuracy of drill guides fabricated in medical-grade, biocompatible materials for static, computer-aided implant surgery (sCAIS). The virtually planned drill guides of ten completed patient cases were printed (n = 40) using professional (Material Jetting (MJ)) and consumer-level three-dimensional (3D) printing technologies, namely, Stereolithography (SLA), Fused Filament Fabrication (FFF), and Digital Light Processing (DLP). After printing and post-processing, the drill guides were digitized using an optical scanner. Subsequently, the drill guide’s original (reference) data and the surface scans of the digitized 3D-printed drill guide were superimposed to evaluate their incongruencies. The accuracy of the 3D-printed drill guides was calculated by determining the root mean square (RMS) values. Additionally, cast models of the planned cases were used to check that the drill guides fitted manually. The RMS (mean ± SD) values for the accuracy of 3D-printed drill guides were—MJ (0.09 ± 0.01 mm), SLA (0.12 ± 0.02 mm), FFF (0.18 ± 0.04 mm), and DLP (0.25 ± 0.05 mm). Upon a subjective assessment, all drill guides could be mounted on the cast models without hindrance. The results revealed statistically significant differences (p < 0.01) in all except the MJ- and SLA-printed drill guides. Although the measured differences in accuracy were statistically significant, the deviations were negligible from a clinical point of view. Within the limits of this study, we conclude that consumer-level 3D printers can produce surgical guides with a similar accuracy to a high-end, professional 3D printer with reduced costs. Full article

To investigate the growth kinetics of the reaction layer and mechanical strength of joined materials, we joined beryllium and reduced-activation ferritic–martensitic steel (F82H) by plasma sintering under various conditions and characterized the joined region. Scanning electron microscopy revealed that the thickness of the reaction layer increased with an increase in the joining time and temperature. Line analyses and elemental mapping using an electron microprobe analyser showed that the reaction layer consists of Be–Fe intermetallic compounds, including Be₁₂Fe, Be₅Fe, and Be₂Fe, with small amounts of chromium and tungsten. Owing to the time and temperature dependence of the reaction-layer thickness, the layer growth of Be–Fe intermetallic compounds obeys the parabolic law, and the activation energy for the reaction-layer growth was 116.2 kJ/mol. The bonding strengths of the joined materials varied inversely with the thickness of the reaction layer. Full article

Fava bean (Vicia faba L.) yields are featured by high variability, influenced by the agro-environmental conditions during the growing seasons. These legume crops are sensitive to hydric and heat stresses. The adaptation depends on the efficiency of specific cultivars to use the available resources to produce biomass. This capacity is determined by the genotype and agronomical management practices. The present work aimed to uncover the influence of Baltic agro-environmental conditions (fava bean cultivar, plant density, climate, and soil features) on yield and protein content. For this, field trials were set under Baltic agro-climatic conditions, in Latvia and Estonia with five commercially available fava bean cultivars, representing broad genetic variation (‘Gloria’, ‘Julia’, ‘Jogeva’, ‘Lielplatones’, and ‘Bauska’). The results evidenced ‘Bauska’, ‘Julia’, and ‘Lielplatones’, as the most productive cultivars in terms of seed yield (4.5, 3.7, and 4.6 t ha⁻¹, respectively) and protein yield (1.39, 1.22, and 1.36 t ha⁻¹, respectively) under Estonian and Latvian agro-climatic conditions. Sowing these specific cultivars at densities of 30–40 seeds m⁻² constitutes sustainable management for fava bean production in conventional cropping systems in the Baltic region. Full article

Chronic kidney disease can progress to end-stage chronic renal disease (ESRD), which requires the use of replacement therapy (dialysis or kidney transplant) in life-threatening conditions. In ESRD, irreversible changes in the kidneys are associated with systemic changes of proinflammatory nature and dysfunctions of internal organs, skeletal muscles, and integumentary tissues. The common components of ESRD pathogenesis, regardless of the initial nosology, are (1) local (in the kidneys) and systemic chronic low-grade inflammation (ChLGI) as a risk factor for diabetic kidney disease and its progression to ESRD, (2) inflammation of the classical type characteristic of primary and secondary autoimmune glomerulonephritis and infectious recurrent pyelonephritis, as well as immune reactions in kidney allograft rejection, and (3) chronic systemic inflammation (ChSI), pathogenetically characterized by latent microcirculatory disorders and manifestations of paracoagulation. The development of ChSI is closely associated with programmed hemodialysis in ESRD, as well as with the systemic autoimmune process. Consideration of ESRD pathogenesis from the standpoint of the theory of general pathological processes opens up the scope not only for particular but also for universal approaches to conducting pathogenetic therapies and diagnosing and predicting systemic complications in severe nephropathies. Full article