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A giant neuron found wrapped around entire mouse brain

A giant neuron found wrapped around entire mouse brain

Allen Institute for Brain Science

3D reconstructions show a 'crown of thorns' shape stemming from a region linked to consciousness.

Like ivy plants that send runners out searching for something to cling to, the brain’s neurons send out shoots that connect with other neurons …

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Latest Research

The newest articles from Advance Online Publication (AOP) and the current issue

LetterAmplified stimulated emission in upconversion nanoparticles for super-resolution nanoscopy
- Yujia Liu
- Yiqing Lu
- Xusan Yang
- Xianlin Zheng
- Shihui Wen
- Fan Wang
- Xavier Vidal
- Jiangbo Zhao
- Deming Liu
- Zhiguang Zhou
- Chenshuo Ma
- Jiajia Zhou
- James A. Piper
- Peng Xi
- Dayong Jin
LetterCrystallization of silicon dioxide and compositional evolution of the Earth’s core
- Kei Hirose
- Guillaume Morard
- Ryosuke Sinmyo
- Koichio Umemoto
- John Hernlund
- George Helffrich
- Stéphane Labrosse
LetterComplement drives glucosylceramide accumulation and tissue inflammation in Gaucher disease
- Manoj K. Pandey
- Thomas A. Burrow
- Reena Rani
- Lisa J. Martin
- David Witte
- Kenneth D. Setchell
- Mary A. Mckay
- Albert F. Magnusen
- Wujuan Zhang
- Benjamin Liou
- Jörg Köhl
- Gregory A. Grabowski
- Complement cascade
- Disease genetics
ArticleIntragenic DNA methylation prevents spurious transcription initiation
- Francesco Neri
- Stefania Rapelli
- Anna Krepelova
- Danny Incarnato
- Caterina Parlato
- Giulia Basile
- Mara Maldotti
- Francesca Anselmi
- Salvatore Oliviero
- DNA methylation
- Transcriptomics
LetterPrefrontal cortex output circuits guide reward seeking through divergent cue encoding
- James M. Otis
- Vijay M. K. Namboodiri
- Ana M. Matan
- Elisa S. Voets
- Emily P. Mohorn
- Oksana Kosyk
- Jenna A. McHenry
- J. Elliott Robinson
- Shanna L. Resendez
- Mark A. Rossi
- Garret D. Stuber
LetterReconstitution of the tubular endoplasmic reticulum network with purified components
- Robert E. Powers
- Songyu Wang
- Tina Y. Liu
- Tom A. Rapoport
- Endoplasmic reticulum
- Membrane structure and assembly
LetterTargeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
- Justin Eyquem
- Jorge Mansilla-Soto
- Theodoros Giavridis
- Sjoukje J. C. van der Stegen
- Mohamad Hamieh
- Kristen M. Cunanan
- Ashlesha Odak
- Mithat Gönen
- Michel Sadelain
ArticleElucidation of the biosynthesis of the methane catalyst coenzyme F₄₃₀
- Simon J. Moore
- Sven T. Sowa
- Christopher Schuchardt
- Evelyne Deery
- Andrew D. Lawrence
- José Vazquez Ramos
- Susan Billig
- Claudia Birkemeyer
- Peter T. Chivers
- Mark J. Howard
- Stephen E. J. Rigby
- Gunhild Layer
- Martin J. Warren
- Biosynthesis
- Enzymes
News and ViewsCardiovascular disease: Commonality with cancer
- Alan R. Tall
- Ross L. Levine
- Cardiovascular biology
- Cell biology
News and ViewsImmunology: T-cell tweaks to target tumours
- Marcela V. Maus
- Immunology
News and ViewsBiochemistry: Origin of a key player in methane biosynthesis
- Tadhg P. Begley
- Biochemistry
- Chemical biology
News and ViewsImmunology: The chronicles of T-cell exhaustion
- Robert A. Amezquita
- Susan M. Kaech
- Immunology
ArticleA simple rule to determine which insolation cycles lead to interglacials
- P. C. Tzedakis
- M. Crucifix
- T. Mitsui
- E. W. Wolff
- Palaeoclimate
- Statistics
LetterSeven temperate terrestrial planets around the nearby ultracool dwarf star TRAPPIST-1
- Michaël Gillon
- Amaury H. M. J. Triaud
- Brice-Olivier Demory
- Emmanuël Jehin
- Eric Agol
- Katherine M. Deck
- Susan M. Lederer
- Julien de Wit
- Artem Burdanov
- James G. Ingalls
- Emeline Bolmont
- Jeremy Leconte
- Sean N. Raymond
- Franck Selsis
- Martin Turbet
- Khalid Barkaoui
- Adam Burgasser
- Matthew R. Burleigh
- Sean J. Carey
- Aleksander Chaushev
- Chris M. Copperwheat
- Laetitia Delrez
- Catarina S. Fernandes
- Daniel L. Holdsworth
- Enrico J. Kotze
- Valérie Van Grootel
- Yaseen Almleaky
- Zouhair Benkhaldoun
- Pierre Magain
- Didier Queloz
- Astrobiology
- Exoplanets
LetterTheory of chaotic orbital variations confirmed by Cretaceous geological evidence
- Chao Ma
- Stephen R. Meyers
- Bradley B. Sageman
LetterEditing and methylation at a single site by functionally interdependent activities
- Mary Anne T. Rubio
- Kirk W. Gaston
- Katherine M. McKenney
- Ian M. C. Fleming
- Zdeněk Paris
- Patrick A. Limbach
- Juan D. Alfonzo

Specials, Supplements & Featured Articles

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Winston Churchill’s essay on alien life found

A newly unearthed article by Winston Churchill reveals that he reasoned like a scientist about the likelihood of extraterrestrials, writes Mario Livio.

image credit: Kurt Hutton/Picture Post/Getty

23 February 2017
Consider drug efficacy before first-in-human trials

Ethical review boards must focus on clinical promise as well as safety to hold the first tests of drugs in humans to a higher standard, say Jonathan Kimmelman and Carole Federico.

image credit: Illustration by Richard Wilkinson

02 February 2017