A comprehensive review of the current literature on post-acute COVID-19, also referred to as long COVID, its pathophysiology and its organ-specific sequelae highlights the need for multidisciplinary follow-up and care of COVID-19 survivors.

The pandemic has been a source of a sometimes overwhelming sense of uncertainty. We asked our readers to share how they have used art to document their experiences.

There has been a lot of hype around the applications of machine learning in medicine. But how is machine learning actually helping bench-to-bedside scientists and clinicians do their jobs?

In an inpatient, randomized controlled crossover trial, participants consumed 550–700 kcal day⁻¹ fewer calories when following a plant-based, low-fat diet with a high glycemic load compared with an animal-based, low-carbohydrate diet with a low glycemic load; weight loss was comparable between the two diets and there were no significant differences in hunger or enjoyment of the meals.

Sera from convalescent individuals with coronavirus disease 2019 and from individuals vaccinated with BNT162b2 have reduced ability to neutralize SARS-CoV-2 variants B1.1.7 and B.1.351, but antibody potency against the variants increases after two vaccine doses.

Single-cell transcriptomics and protein expression analyses of salivary glands and gingiva, along with the detection of infectious virus and virus-specific antibodies in saliva from SARS-CoV-2-infected individuals, support a potential role for the oral cavity in COVID-19 pathogenesis.

A new genome editing strategy can normalize the β-globin:α-globin balance in human hematopoietic stem cells from patients with β-thalassemia and restore functional adult hemoglobin tetramers in patient-derived red blood cells.

Artificial intelligence coupled with wireless home sensors can monitor the use of insulin pens and inhalers by patients and alert of errors in self-medication in an unobtrusive manner.

This study of a cohort of over 3,500 pregnant women in six different populations worldwide identifies specific fetal cranial growth trajectories, measured by serial ultrasound scans early in gestation, that are related to postnatal growth and neurodevelopment up to the key milestone age of 2 years.

Implantation of a perfusable device into the epicardium enables delivery of therapeutic agents and infiltration of reparative cells into the heart, amplifying the therapeutic effects of FGF-23 in a rat model of myocardial infarction.

Atherosclerosis promotes clonal hematopoiesis by spurring the proliferation of hematopoietic stem cells, which in turn fuels further atherosclerosis and elevates the risk of heart disease.

Targeted vector-control strategies offer cost savings for anti-malaria programs.

Revisiting the challenges of the beginning of the COVID-19 pandemic, when doctors and patients had to make treatment decisions without the support of scientific evidence, can provide valuable clues on how to prepare for future pandemics.

Engineered T cells that recognize a protein expressed on myeloma cells show promise in a clinical trial.

New vaccines and an expansion of vaccination programs over the past two decades have substantively reduced childhood mortality in low- and middle-income countries.