In two randomized trials of Zaire Ebola vaccines, safety and immune responses in adults and children were assessed for three regimens with two different vaccines. All three induced immune responses lasting at least 1 year.

In this study, a large repeat expansion in a noncoding part of FGF14 was found to cause late-onset cerebellar ataxia, which underscores the importance of noncoding regions in the search for causes of disease.

Glofitamab, a bifunctional antibody, was given to 154 patients with relapsed or refractory DLBCL. Complete response occurred in 39%; most of these responses were ongoing at 12 months. Cytokine release syndrome was common.

In this trial, adolescents with obesity assigned to weekly subcutaneous semaglutide plus lifestyle intervention had a greater reduction in BMI than those who received lifestyle intervention alone.

Talquetamab, a bifunctional antibody, directs activated T cells to tumor. In this study, up to 70% of the patients with relapsed or refractory myeloma had a response to this agent.

This editorial explains how monoclonal antibodies and bispecific monoclonal antibodies are made and their application in oncology.

A 21-year-old woman presented with fatigue, weight gain, abdominal pain, and an adrenal mass. After the administration of dexamethasone, the cortisol level was 9.1 μg per deciliter (reference value, <1.8). Management decisions were made.

Hemochromatosis is a group of inherited disorders that cause iron overload due to failed regulation of hepcidin. The authors review the literature on hemochromatosis and provide an integrated approach to management.

A 55-year-old man with a history of sarcoidosis was admitted 7 months after kidney transplantation for nephrocalcinosis because of fatigue, weight loss, and new pulmonary nodules. What is the diagnosis?